Look at alternant therapies that are not average CYP3A inducers throughout therapy with mitapivat. If not able to steer clear of coadministration, keep track of Hb and titrate beyond 50 mg BID, if essential, but don't exceed mitapivat dose of 100 mg BID. .pentobarbital boosts effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use